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The study is published in Scientific Reports: "The human gut microbiome regulates the development of type 2 diabetes."
A large number of studies have indicated a link between the gut microbiota and development of insulin resistance, a disorder that is characterized by hyperglycemia and increased blood levels of insulin.
Type 2 diabetes is a leading cause Kmart pharmacy generic drug price list of death. Researchers have suggested that the disease develops when immune system becomes out-of-sync with the developing insulin-producing insulinoma cells in the pancreas.
"When the body is in a state of insulin resistance, cells within the gut and in pancreas become misdirected, causing the to produce more glucose than it should, leading to hyperinsulinemia," says Professor Gerd Binkley, of the Institute Diabetes, Diabetes Care and Obesity Research at the Charité – Universitätsmedizin Berlin (DUM) and first author of the study.
The human gut microbiota was first characterized by the human microbiota transplantation (HMTP). This procedure uses a genetically engineered bacterial strain that can "self-renew" and grow in the recipient's gut, allowing researchers to measure the influence of gut microbiome on diabetes.
In the current study investigators studied impact of the gut microbiome on pathogenesis of insulin resistance in mice. The intestinal microbe Akkermansia, commonly found in the human gastrointestinal system, was shown to play critical Bringing nolvadex into australia roles in the development of type 2 diabetes. This effect was even more pronounced when Akkermansia was cultured in the presence of Akkermansia-resistant E. coli.
The investigators also demonstrated that Akkermansia was able to suppress the development of insulin resistance by activating the transcription factor Insulin like growth 1 (IGF-1).
"Akkermansia was not only capable of restoring insulin sensitivity, but increased insulin-mediated glycogen storage. Together, these results show how Akkermansia can influence the development of type 2 diabetes," says Professor Gerd Binkley.
The researchers conclude that Akkermansia-containing bacteria have the potential to reduce development of type 2 diabetes, thereby possibly reducing the burden of disease in people with type 2 diabetes.
Reference
"The human gut microbiota regulates the development of type 2 diabetes," Gerd Binkley, Georg N. Wolk and J. K. Binkley, Scientific Reports (2016).
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